Least sedating ssri
It provides an option when the patient is unable to tolerate anything else.
A different medication often works even if the first option has been unsuccessful.
Up to a third of patients have a relatively slow response to antidepressants.
Dose titration for both SSRIs and TCAs is usually slower for anxious patients as they appear more sensitive to side effects.
It is not unusual for anxious patients to have more anxiety during the titration of SSRIs.